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Open full calculatorSide effects and safety: 5 videos, about 111 minutes in total. Watch in order; each write-up assumes the ones before it.
1 of 5 · 6:57
Ozempic in the ER: Side Effects of GLP-1 Receptor Agonists
Nick Sterling, MD, PhD · Original
An emergency physician ranks the GLP-1 problems he sees: nausea and vomiting, dehydration progressing to acute kidney injury, starvation ketosis, muscle loss in people who are not strength training or eating enough protein, low mood, and gastroparesis as an honourable mention.
Read the full fact-check2 of 5 · 12:16
Top 5 GLP-1 Side Effects and How to Fix Them | Doctor Explains
Dr. Spencer Nadolsky · Original
An obesity medicine physician on nausea, constipation, reflux, diarrhoea and fatigue: nausea peaks early and fades, constipation persists, do not escalate until nausea is mild, avoid heavy fatty meals, hydrate, add fibre, and how his clinic uses antiemetics, laxatives and acid suppression when food changes are not enough.
Read the full fact-check3 of 5 · 27:47
#189 GLP-1 Receptor Agonist Recommendations Revisited
Anesthesia Patient Safety Foundation (APSF) · Original
The Anesthesia Patient Safety Foundation podcast on retained gastric contents: two case reports despite standard fasting, the June 2023 ASA guidance to hold weekly agents one week and daily agents on the day before elective procedures, and gastric ultrasound as a bedside check.
Read the full fact-check4 of 5 · 11:49
ENP107: Compounded Obesity Medications
An Endocrine Society podcast with an NYU endocrinologist on compounded GLP-1s: what compounding is, why it was permitted during the shortage, the shortage end dates, that compounded products are not FDA approved, and the dosing confusion caused by units, millilitres and reconstitution.
Read the full fact-check5 of 5 · 52:30
Managing the Gastrointestinal Side Effects of GLP-1s: Focus on Nutrition & Lifestyle Interventions
Stanford Health Care · Original
A Stanford Health Care dietitian's hour on GI side effects with trial ranges: nausea in about a quarter of participants at week four falling to about 15 percent by week eight and 5.5 percent by week 56, dose dependence across STEP, SUSTAIN, SCALE and LEAD, plus small frequent meals, less fat, more protein and liquids on bad days.
Read the full fact-check
Watch order and why
The emergency physician goes first because his list, nausea, dehydration and kidney injury, ketosis, muscle loss, mood, is what goes wrong when early effects are ignored. Dr. Nadolsky follows with what to do about each common effect and when a clinic adds medication. The APSF podcast covers the one safety question that involves other clinicians, anaesthesia, and its fact-check explains how the guidance changed in 2024. The Endocrine Society podcast on compounded products is fourth, with its sponsorship disclosed and its unsourced figures flagged. The Stanford dietitian's webinar closes with the week-by-week trial percentages.
What the labels say, in one paragraph
Both the Wegovy and Zepbound labels carry a boxed warning about thyroid C-cell tumours in rodents and contraindicate use with a personal or family history of medullary thyroid carcinoma or MEN 2. Warnings and precautions cover acute pancreatitis, gallbladder disease, hypoglycaemia with insulin or sulfonylureas, acute kidney injury from dehydration, hypersensitivity, diabetic retinopathy complications in type 2 diabetes, suicidal behaviour and ideation, and, added more recently, pulmonary aspiration under anaesthesia and severe gastrointestinal disease. The adverse reactions tables give the GI rates quoted throughout this playlist.
The compounded question
FormBlends dispenses compounded semaglutide and tirzepatide through licensed pharmacies. Compounded products are not FDA approved, are not checked by the FDA for safety, effectiveness or quality, and are not interchangeable with the brand products the labels describe. Every fact-check in this playlist says so where it is relevant. For how to verify a compounding pharmacy's licence, see Compounding Explained; for a side-effect diary, FormBlends Tools and Templates; for the labs worth watching, the GLP-1 Lab Guide.
Sources
- Wegovy (semaglutide) prescribing information, sections 5 and 6, DailyMed set id ee06186f-2aa3-4990-a760-757579d8f77b Accessed September 4, 2026.
- Zepbound (tirzepatide) prescribing information, sections 5 and 6, DailyMed set id 487cd7e7-434c-4925-99fa-aa80b1cc776b Accessed September 4, 2026.
- FDA: FDA's concerns with unapproved GLP-1 drugs used for weight loss Accessed September 4, 2026.
Canonical URL: https://formblendsvideos.com/playlists/side-effects-and-safety. Written by the FormBlends editorial team. This page is educational and is not medical advice; see the medical disclaimer.